To investigate the effect of Kawasaki syndrome on left ventricular function, we studied 52 patients with Kawasaki syndrome at initial visit and after 3 months (36 patients).
Using Pulsed Doppler echocardiogram,we obtained aortic velocity (peak and mean), acceleration time(AT),ejection time(ET), ratio of AT to ET(AT/ET), acceleration (peak and mean) and velocity time integral and mitral velocity of E and A waves(peak
and
mean) and velocity time integral.
Mitral time for peak velocity time integral.
Mitral time for peak velocity was significantly prolonged in Kawasaki syndrome,being a mean(± SD) of 66.2(±14) msec in the control group, 79.2( ±13)msec at initial vist(p< 0.05) and 79.4(±13) msec after 3 months (p<0.05).
Aortic peak acceleration was significantly decreased in Kawasaki syndrome being a mean(± SD) of 2590( ±785) cm/sec2 after 3 months (P<0.05).Aortic mean acceleration was also significantly decreased in Kawasaki syndrome being a mean( ±SD) of
1575(
±542)cm/sec2 in the control group, 1198( ±351)cm/sec2at initial visit(p<0.05)and 1124 ±275cm/sec2 after 3 months(p<0.01). Aortic acceleration time was significantly prolonged in Kawasaki svndrome being a mean(± SD) of 62(± 13) msec in the
control
group, 72( ±13) msec at initial visit(p< 0.05) and 76(± 16) msec in the control group, 72(± 13) msec at initial visit(p< 0.05) and 76(± 16) msec after 3 months (p< 0.01).
We conclude that early abnormalities of left ventricular function, as assessed by echocardiograpy,gencrally persist after 3 months of onset.
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